abstract：:The nature and definition of schizotypy, as the latent liability for schizophrenia capable of generating various phenotypic and endophenotypic outcomes, is reviewed. The proceedings of the 2017 meeting of the International Consortium on Schizotypy Research are included in this Special Section and they are presented as...

journal_title：Schizophrenia bulletin

authors： Lenzenweger MF

更新日期：2018-10-15 00:00:00

abstract：:It is increasingly evident that the brain is not truly an immune privileged site and that cells of the central nervous system are sensitive to the inflammation generated when the brain is fighting off infection. Among the many microorganisms that have access to the brain, the apicomplexan protozoan Toxoplasma gondii h...

journal_title：Schizophrenia bulletin

authors： Xiao J,Prandovszky E,Kannan G,Pletnikov MV,Dickerson F,Severance EG,Yolken RH

更新日期：2018-08-20 00:00:00

abstract：:Identifying distinctive subtypes of schizophrenia could ultimately enhance diagnostic and prognostic accuracy. We aimed to uncover neuroanatomical subtypes of chronic schizophrenia patients to test whether stratification can enhance computer-aided discrimination of patients from control subjects. Unsupervised, data-dr...

journal_title：Schizophrenia bulletin

authors： Dwyer DB,Cabral C,Kambeitz-Ilankovic L,Sanfelici R,Kambeitz J,Calhoun V,Falkai P,Pantelis C,Meisenzahl E,Koutsouleris N

更新日期：2018-08-20 00:00:00

abstract：:Schizophrenia (SZ) is a devastating mental disease caused by complex genetic and environmental factors. The pathological process and clinical manifestation of SZ are heterogeneous among patients, which hampers precise diagnosis and treatment of the disease. Since no objective marker for SZ has been established today, ...

journal_title：Schizophrenia bulletin

authors： Sun L,Yang X,Jiang J,Hu X,Qing Y,Wang D,Yang T,Yang C,Zhang J,Yang P,Wang P,Cai C,Wang J,He L,Wan C

更新日期：2018-06-06 00:00:00

abstract：:Schizophrenia (SCZ) is associated with differences in subcortical brain volumes and intracranial volume (ICV). However, little is known about the underlying etiology of these brain alterations. Here, we explored whether brain structure volumes and SCZ share genetic risk factors. Using conditional false discovery rate ...

journal_title：Schizophrenia bulletin

authors： Smeland OB,Wang Y,Frei O,Li W,Hibar DP,Franke B,Bettella F,Witoelar A,Djurovic S,Chen CH,Thompson PM,Dale AM,Andreassen OA

更新日期：2018-06-06 00:00:00

abstract：:Patients describe experiencing personal recovery despite ongoing symptoms of psychosis. The aim of the current research was to perform a meta-analysis investigating the relationship between clinical and personal recovery in patients with schizophrenia spectrum disorders. A comprehensive OvidSP database search was perf...

journal_title：Schizophrenia bulletin

authors： Van Eck RM,Burger TJ,Vellinga A,Schirmbeck F,de Haan L

更新日期：2018-04-06 00:00:00

abstract：Objective:Evidence suggests that social skills training (SST) is an efficacious intervention for negative symptoms in psychosis, whereas evidence of efficacy in other psychosis symptom domains is limited. The current article reports a comprehensive meta-analytic review of the evidence for SST across relevant outcome me...

journal_title：Schizophrenia bulletin

authors： Turner DT,McGlanaghy E,Cuijpers P,van der Gaag M,Karyotaki E,MacBeth A

更新日期：2018-04-06 00:00:00

abstract：Background:The diagnostic and prognostic significance of the DSM-5-defined Attenuated Psychosis Syndrome (DSM-5-APS) in individuals undergoing an ultra high risk (UHR) clinical assessment for suspicion of psychosis risk is unknown. Methods:Prospective cohort study including all consecutive help-seeking individuals und...

journal_title：Schizophrenia bulletin

authors： Fusar-Poli P,De Micheli A,Cappucciati M,Rutigliano G,Davies C,Ramella-Cravaro V,Oliver D,Bonoldi I,Rocchetti M,Gavaghan L,Patel R,McGuire P

更新日期：2018-02-15 00:00:00

abstract：Background:Delta band (1-4 Hz) neuronal responses support the precision and stability of auditory processing, and a deficit in delta band synchrony may be relevant to auditory domain symptoms in schizophrenia patients. Methods:Delta band synchronization elicited by a 2.5 Hz auditory steady state response (ASSR) paradi...

journal_title：Schizophrenia bulletin

authors： Puvvada KC,Summerfelt A,Du X,Krishna N,Kochunov P,Rowland LM,Simon JZ,Hong LE

更新日期：2018-02-15 00:00:00

abstract：:A major factor associated with poor prognostic outcome after a first psychotic break is cannabis misuse, which is prevalent in schizophrenia and particularly common in individuals with recent-onset psychosis. Behavioral interventions aimed at reducing cannabis use have been unsuccessful in this population. Cannabidiol...

journal_title：Schizophrenia bulletin

authors： Hahn B

更新日期：2018-01-13 00:00:00

abstract：:Lifetime prevalence of psychotic disorders varies widely across studies. Epidemiological surveys have rarely examined prevalences of specific psychotic disorders other than schizophrenia, and the majority used a single-phase design without employing clinical reappraisal interview for diagnostic verification. The curre...

journal_title：Schizophrenia bulletin

authors： Chang WC,Wong CSM,Chen EYH,Lam LCW,Chan WC,Ng RMK,Hung SF,Cheung EFC,Sham PC,Chiu HFK,Lam M,Lee EHM,Chiang TP,Chan LK,Lau GKW,Lee ATC,Leung GTY,Leung JSY,Lau JTF,van Os J,Lewis G,Bebbington P

更新日期：2017-10-21 00:00:00

abstract：Background:Motor abnormalities (MAs) of severe mental disorders have been traditionally neglected both in clinical practice and research, although they are an increasing focus of attention because of their clinical and neurobiological relevance. For historical reasons, most of the literature on MAs has been focused to ...

journal_title：Schizophrenia bulletin

authors： Peralta V,Cuesta MJ

更新日期：2017-09-01 00:00:00

abstract：:Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric dise...

journal_title：Schizophrenia bulletin

authors： Chou IJ,Kuo CF,Huang YS,Grainge MJ,Valdes AM,See LC,Yu KH,Luo SF,Huang LS,Tseng WY,Zhang W,Doherty M

更新日期：2017-09-01 00:00:00

abstract：:Child maltreatment is a widespread public health problem associated with a range of mental health disorders later in life. In order to effectively address these disorders, there is a need to understand more about the mental health consequences of different types of child maltreatment. This study examines the associati...

journal_title：Schizophrenia bulletin

authors： Abajobir AA,Kisely S,Scott JG,Williams G,Clavarino A,Strathearn L,Najman JM

更新日期：2017-09-01 00:00:00

abstract：Objective:A proinflammatory imbalance in the tumor necrosis factor (TNF) system may contribute to the pathogenesis of schizophrenia (SCZ) and bipolar disorders (BDs) and related comorbidities. We investigated the relative distribution of TNF-related molecules in blood and dorsolateral prefrontal cortex (DLPFC) in these...

journal_title：Schizophrenia bulletin

authors： Hoseth EZ,Ueland T,Dieset I,Birnbaum R,Shin JH,Kleinman JE,Hyde TM,Mørch RH,Hope S,Lekva T,Abraityte AJ,Michelsen AE,Melle I,Westlye LT,Ueland T,Djurovic S,Aukrust P,Weinberger DR,Andreassen OA

更新日期：2017-07-01 00:00:00

abstract：:Schizophrenia has been associated with heightened stress responsivity in adolescence that precedes onset of psychosis. We now report that multiple stressors during adolescence in normal rats leads to deficits in adults analogous to that seen in schizophrenia patients. Moreover, impairment of stress control by lesion o...

journal_title：Schizophrenia bulletin

authors： Gomes FV,Grace AA

更新日期：2017-05-01 00:00:00

abstract：:Migration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism is through elevations in striatal dopamine synthesis and release. The objective of this research was to determine whether striatal dopamine function is elevated in immigrants compared to non...

journal_title：Schizophrenia bulletin

authors： Egerton A,Howes OD,Houle S,McKenzie K,Valmaggia LR,Bagby MR,Tseng HH,Bloomfield MA,Kenk M,Bhattacharyya S,Suridjan I,Chaddock CA,Winton-Brown TT,Allen P,Rusjan P,Remington G,Meyer-Lindenberg A,McGuire PK,Mizrahi R

更新日期：2017-03-01 00:00:00

abstract：:Delusions, the fixed false beliefs characteristic of psychotic illness, have long defied understanding despite their response to pharmacological treatments (e.g., D2 receptor antagonists). However, it can be challenging to discern what makes beliefs delusional compared with other unusual or erroneous beliefs. We sugge...

journal_title：Schizophrenia bulletin

authors： Feeney EJ,Groman SM,Taylor JR,Corlett PR

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Brief Limited Intermittent Psychotic Symptoms (BLIPS) are key inclusion criteria to define individuals at ultra high risk for psychosis (UHR). Their diagnostic and prognostic significance is unclear. OBJECTIVES:To address the baseline diagnostic relationship between BLIPS and the ICD-10 categories and exami...

journal_title：Schizophrenia bulletin

authors： Fusar-Poli P,Cappucciati M,De Micheli A,Rutigliano G,Bonoldi I,Tognin S,Ramella-Cravaro V,Castagnini A,McGuire P

更新日期：2017-01-01 00:00:00

abstract：:Childhood trauma (CT) has been identified as a potential risk factor for the onset of psychotic disorders. However, to date, there is limited consensus with respect to which symptoms may ensue after exposure to trauma in early life, and whether specific pathways may account for these associations. The aim of the prese...

journal_title：Schizophrenia bulletin

authors： Isvoranu AM,van Borkulo CD,Boyette LL,Wigman JT,Vinkers CH,Borsboom D,Group Investigators.

更新日期：2017-01-01 00:00:00

abstract：:Family interventions for first-episode psychosis (FEP) are an integral component of treatment, with positive effects mainly on patients' mental state and relapse rate. However, comparatively little attention has been paid to the effects of family interventions on caregivers' stress coping and well-being, especially in...

journal_title：Schizophrenia bulletin

authors： Chien WT,Thompson DR,Lubman DI,McCann TV

更新日期：2016-11-01 00:00:00

abstract：:Although weight gain is a serious but variable adverse effect of antipsychotics that has genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of antipsychotic-related weight gain is missing. In this review, random effects meta-analyses were conducted for dominant and recessive models on association...

journal_title：Schizophrenia bulletin

authors： Zhang JP,Lencz T,Zhang RX,Nitta M,Maayan L,John M,Robinson DG,Fleischhacker WW,Kahn RS,Ophoff RA,Kane JM,Malhotra AK,Correll CU

更新日期：2016-11-01 00:00:00

abstract：:Abnormalities in both time processing and dopamine (DA) neurotransmission have been observed in schizophrenia. Time processing seems to be linked to DA neurotransmission. The cognitive dysmetria hypothesis postulates that psychosis might be a manifestation of the loss of coordination of mental processes due to impaire...

journal_title：Schizophrenia bulletin

authors： Lošák J,Hüttlová J,Lipová P,Marecek R,Bareš M,Filip P,Žubor J,Ustohal L,Vanícek J,Kašpárek T

更新日期：2016-11-01 00:00:00

abstract：:Disruption of sleep/wake cycles is common in patients with schizophrenia and correlates with cognitive and affective abnormalities. Mice deficient in stable tubule only polypeptide (STOP) show cognitive, behavioral, and neurobiological deficits that resemble those seen in patients with schizophrenia, but little is kno...

journal_title：Schizophrenia bulletin

authors： Profitt MF,Deurveilher S,Robertson GS,Rusak B,Semba K

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Over the past 30 years, illness management programs and cognitive-behavioral therapy for psychosis have gained prominence in the treatment of schizophrenia. However, little is known about the long-term benefits of these types of programs when delivered during inpatient treatment following a symptom exacerbati...

journal_title：Schizophrenia bulletin

authors： Schaub A,Mueser KT,von Werder T,Engel R,Möller HJ,Falkai P

更新日期：2016-07-01 00:00:00

abstract：:Identifying predictors and elucidating the fundamental mechanisms underlying onset of psychosis are critical for the development of targeted preemptive interventions. This article presents a selective review of findings on risk prediction algorithms and potential mechanisms of onset in youth at clinical high-risk for ...

journal_title：Schizophrenia bulletin

authors： Cannon TD

更新日期：2016-07-01 00:00:00

abstract：:To better characterize hippocampal pathophysiology in schizophrenia, we conducted a longitudinal study evaluating hippocampal functional connectivity during resting state, using seeds prescribed in its anterior and posterior regions. We enrolled 34 unmedicated patients with schizophrenia or schizoaffective disorder (S...

journal_title：Schizophrenia bulletin

authors： Kraguljac NV,White DM,Hadley N,Hadley JA,Ver Hoef L,Davis E,Lahti AC

更新日期：2016-07-01 00:00:00

abstract：:Disrupted thalamo-cortical connectivity is regarded as a core psychopathology in patients diagnosed with schizophrenia. However, whether the thalamo-cortical white matter connectivity is disrupted before the onset of psychosis is still unknown. To determine this gap in knowledge, the strength of thalamo-cortical white...

journal_title：Schizophrenia bulletin

authors： Cho KI,Shenton ME,Kubicki M,Jung WH,Lee TY,Yun JY,Kim SN,Kwon JS

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22...

journal_title：Schizophrenia bulletin

authors： Vangkilde A,Olsen L,Hoeffding LK,Pedersen CB,Mortensen PB,Werge T,Trabjerg B

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:There is evidence of a positive association between insight and depression among patients with schizophrenia. Self-stigma was shown to play a mediating role in this association. We attempted to broaden this concept by investigating insight as a potential moderator of the association between depressive sympto...

journal_title：Schizophrenia bulletin

authors： Krupchanka D,Katliar M

更新日期：2016-05-01 00:00:00

abstract：:While the role of childhood adversity in increasing the risk of psychosis has been extensively investigated, it is not clear what the impact of early adverse experiences is on the outcomes of psychotic disorders. Therefore, we investigated associations between childhood adversity and 1-year outcomes in 285 first-prese...

journal_title：Schizophrenia bulletin

authors： Trotta A,Murray RM,David AS,Kolliakou A,O'Connor J,Di Forti M,Dazzan P,Mondelli V,Morgan C,Fisher HL

更新日期：2016-03-01 00:00:00

abstract：:People with serious mental illness (SMI) have mortality rates 2 to 3 times higher than the overall US population, largely due to cardiovascular disease. The prevalence of cardiovascular risk factors such as obesity and diabetes mellitus and other conditions, such as HIV/AIDS, is heightened in this group. Based on the ...

journal_title：Schizophrenia bulletin

authors： McGinty EE,Baller J,Azrin ST,Juliano-Bult D,Daumit GL

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Hippocampal abnormalities have been widely studied in schizophrenia spectrum populations including those at ultrahigh risk (UHR) for psychosis. There have been inconsistent findings concerning hippocampal morphology prior to and during the transition to psychosis, and little is known about how specific sub...

journal_title：Schizophrenia bulletin

authors： Dean DJ,Orr JM,Bernard JA,Gupta T,Pelletier-Baldelli A,Carol EE,Mittal VA

更新日期：2016-01-01 00:00:00

abstract：:A number of recent articles, many appearing in Schizophrenia Bulletin, signal a renewed interest in phenomenological approaches to our understanding of schizophrenia. These approaches conceptualize schizophrenia as a disorder of altered self-awareness and decreased prereflective social attunement, which may manifest a...

journal_title：Schizophrenia bulletin

authors： Nour MM,Barrera A

更新日期：2015-11-01 00:00:00

abstract：:Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Re...

journal_title：Schizophrenia bulletin

authors： Gong Q,Dazzan P,Scarpazza C,Kasai K,Hu X,Marques TR,Iwashiro N,Huang X,Murray RM,Koike S,David AS,Yamasue H,Lui S,Mechelli A

更新日期：2015-11-01 00:00:00

abstract：:Because negative symptoms, including motivational deficits, are a critical unmet need in schizophrenia, there are many ongoing efforts to develop new pharmacological and psychosocial interventions for these impairments. A common challenge of these studies involves how to evaluate and select optimal endpoints. Currentl...

journal_title：Schizophrenia bulletin

authors： Green MF,Horan WP,Barch DM,Gold JM

更新日期：2015-09-01 00:00:00

abstract：:Aerobic exercise has been shown to improve symptoms in multiepisode schizophrenia, including cognitive impairments, but results are inconsistent. Therefore, we evaluated the effects of an enriched environment paradigm consisting of bicycle ergometer training and add-on computer-assisted cognitive remediation (CACR) tr...

journal_title：Schizophrenia bulletin

authors： Malchow B,Keller K,Hasan A,Dörfler S,Schneider-Axmann T,Hillmer-Vogel U,Honer WG,Schulze TG,Niklas A,Wobrock T,Schmitt A,Falkai P

更新日期：2015-07-01 00:00:00

abstract：:Clozapine can cause severe adverse effects yet it is associated with reduced mortality risk. We test the hypothesis this association is due to increased clinical monitoring and investigate risk of premature mortality from natural causes. We identified 14 754 individuals (879 deaths) with serious mental illness (SMI) i...

journal_title：Schizophrenia bulletin

authors： Hayes RD,Downs J,Chang CK,Jackson RG,Shetty H,Broadbent M,Hotopf M,Stewart R

更新日期：2015-05-01 00:00:00

abstract：:The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks derived from brain structural and functional imaging. Individuals with high schizotypy (n = 35) and low schizotypy (n = 34) controls were screened using the Schizotypal Personality Questionnaire...

journal_title：Schizophrenia bulletin

authors： Wang Y,Yan C,Yin DZ,Fan MX,Cheung EF,Pantelis C,Chan RC

更新日期：2015-03-01 00:00:00

abstract：:Little is known about the neurobiological factors that determine functional outcome in people at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical responses during a cognitive task and thalamic glutamate levels were associated with subsequent functional outcome. Sixty subjects par...

journal_title：Schizophrenia bulletin

authors： Allen P,Chaddock CA,Egerton A,Howes OD,Barker G,Bonoldi I,Fusar-Poli P,Murray R,McGuire P

更新日期：2015-03-01 00:00:00